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apalutamide will decrease the extent or impact of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with drugs which can be CYP3A4 substrates may end up in decreased exposure to those medicines.Findings from the number of early animal and mobi

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